AfrECC: Fighting Esophageal Cancer in Africa

The African Esophageal Cancer Consortium (AfrECC) is dedicated to reducing the burden of esophageal cancer in Africa through clinical care, education, prevention and research.

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A Critical Health Crisis

Esophageal cancer claims 500,000 lives annually worldwide, with a high prevalence in Eastern Africa. In 2022 alone, Africa saw 30,000 new cases and 28,000 deaths.  EC is the general term for esophageal cancer. ESCC refers to the specific type of EC that makes up 85% of cases of EC worldwide. Over 90% of EC in the high-risk areas is esophageal squamous cell carcinoma (ESCC). In Africa, most EC patients present with advanced cancer and live only 3-6 months.

Current AfrECC sites

Mosambique

Maputo

Kenya

Bomet
Eldoret
Nairobi

Ethiopia

Adis Ababa

Tanzania

Dar-es-Salaam
Moshi

Malawi

Lilongwe
Blantyre

South Africa

Johannesburg
East London
Pietermaritzburg

Uganda

Jinja

Zambia

Lusaka

AfrECC Foundation

The AfrECC Foundation, established in 2024, is a 501(c)(3) tax-exempt public non-profit organization dedicated to supporting the African Esophageal Cancer Consortium (AfrECC). Its mission includes developing a strategic plan, creating a sustainability model, maintaining an ongoing dialogue with the AfrECC Steering Committee, and supporting AfrECC activities. One of its goals is to raise funds to complement resources obtained through academic grants and equipment donations.

The AfrECC Foundation hosted a reception at Digestive Disease Week in Washington, DC, in May 2024, to discuss its mission. Attendees included Board members, American and international guests, and leading experts in esophageal cancer, including physicians, scientists, business leaders, and advocates for AfrECC.

Past Work

AfrECC Clinical Studies

Endoscopic capacity surveys revealed major gaps in equipment and trained staff.

  • An endoscopic screening study showed prevalent dysplasia, a curable precursor of ESCC.
  • We have demonstrated that capsule sponges are acceptable.
  • Quality of life and survival studies are on-going.
  • We are increasing access to palliation using self-expanding metal stents, through an AfrECC Stent Access Initiative, focused upon training endoscopy teams and facilitating access to subsidized stents. This work is supported by Boston Scientific Corporation which has donated over 1000 stents.

Link to AfrECC publications

AfrECC Etiological Studies

Addressed gaps in endoscopic capacity and equipment.  In the past 10 years, we have completed 7 case-control studies of ESCC in 4 countries, including 2400 patients with genomic material.

The risk factors found include:

  • Indoor air pollution
  • Drinking hot beverages
  • Poor oral health
  • Tobacco and alcohol


Link to AfrECC publications

Current Needs

Every Contribution Counts!

Your support can make a crucial difference in our mission. Every contribution of yours helps save lives.

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Stories of Hope

This patient was 25 years old and pregnant, when she was diagnosed with esophageal cancer. Dr Russ White performed curative surgery while she was pregnant and his colleagues in Obstetrics delivered her baby at term. Since that time she has had 4 other healthy babies.

Before: This man was seen at age 22 unable to swallow his own saliva and was seriously malnourished as is seen in the images. He had no metastatic disease but initially could not undergo surgery because of his nutritional status. An esophageal stent was placed to allow him to swallow and gain weight.

After: He is shown with Dr Russ White, Chief Surgeon, Tenwek Hospital in Kenya after his operation which successfully removed all the esophageal cancer.

Prior to placement of esophageal stent neither of these patients could swallow their own saliva. Because they presented at such a late stage, neither were candidates for curative therapy. However, stent placement would dramatically improve the quality of their lives, provide some dignity, and allow them to participate in social situations with friends and relatives.

Our Collaborations

Has been the most significant supporter of AfrECC, providing equipment, guidance, and support for training courses

Has provided support for legal services

Has developed AfrECC Website

FAQs

What is AfrECC?
What is the AfrECC Foundation?
What is the role of the AfrECC Foundation Board?
What are AfrECC's most important needs?
How does AfrECC receive funding?
The work of AfrECC takes place in Africa and the benefits to African patients can be seen. However, is there any relevance for a similar patient in the United States or other countries besides those in Africa?
In addition to the work of AfrECC, being beneficial to patients worldwide, can the information be
used by American doctors and scientists and those in other countries?